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China, Chinese Factory Supply 3- (2, 4-dimethoxybenzylidene) Anabaseine/Gts-21 (DMXB-A) CAS 156223-05-11 Industrial Products Supplier Manufacturer Details, price list catalog:
China Industrial Products Supplier Manufacturer List Catalog
Biochemical4-dimethoxybenzylidene) Anabaseine/Gts-21 (DMXB-A) CAS 156223-05-13- (2 4-dimethoxybenzylidene) AnabaseineCAS 156223-05-1
Shanghai Worldyang Chemical Co., Ltd.
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Product Description Product Name: 3-(2,4-Dimethoxybenzylidene)anabaseine (GTS-21, DMXB-A)CAS Number: 156223-05-1Appearance: White PowderPurity: 99%Product Description:3-(2,4-Dimethoxybenzylidene)anabaseine, also known as GTS-21 (DMXB-A), is a selective α7 nicotinic acetylcholine receptor (α7-nAChR) agonist with additional antagonistic activity on α4β2 nAChR (Ki = 20 nM) and 5-HT3A receptors (IC50 = 3.1 μM). This compound has been widely studied for its anti-inflammatory and cognitive-enhancing properties, making it a valuable tool in neuroscience and therapeutic research.Biological Activity:Target Affinity:α7-nAChR: Selective agonist.α4β2 nAChR: High-affinity antagonist (Ki = 20 nM).5-HT3A Receptor: Antagonist (IC50 = 3.1 μM).Mechanism of Action:Activates α7-nAChR to promote anti-inflammatory responses and cognitive enhancement.Inhibits 5-HT3A receptor activity, potentially contributing to its neuroprotective effects.In Vitro Studies:Binds to human α4β2 nAChR with 100-fold higher potency than to human α7-nAChR.Demonstrates differential potency compared to (-)-nicotine, with 18-fold and 2-fold reduced activity at α4β2 and α7 nAChRs, respectively.In Vivo Studies:Animal Model: C57BL/6 mice irradiated with 12 Gy to induce radiation-induced lung injury (RILI).Dosage: 4 mg/kg administered intraperitoneally on days 1, 3, 7, 14, and 21.Results:Reduced pulmonary inflammatory infiltrate and fibrosis in radiation-treated mice.Demonstrated protective effects against radiation-induced lung injury.Applications:Neuroscience Research: Investigated for its role in enhancing cognition and protecting against neuroinflammation.Therapeutic Development: Potential applications in treating cognitive deficits and inflammatory conditions.Radiation Injury Studies: Shown to mitigate radiation-induced tissue damage, making it a candidate for further studies in protective therapeutics.Storage Information:Conditions: Store at 2-8°C in a tightly sealed container to ensure product stability.Features:High Purity: Ensures reliability in experimental outcomes.Selective Activity: Effective for targeted research applications in neuroscience and inflammation.Versatile Research Tool: Applicable in cognitive, anti-inflammatory, and radioprotection studies.For further details or inquiries about packaging and bulk orders, please contact us.
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