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China, Chinese L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-11 Industrial Products Supplier Manufacturer Details, price list catalog:
China Industrial Products Supplier Manufacturer List Catalog
Pharmaceutical ChemicalsVitaminNutritional Supplement
HN Langyue Biotech Co., Ltd.
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Product Description Product Information:Product Name:Levomefolate calciumSynonyms:(S)-2-(4-((((S)-2-AMino-5-Methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid, calciuM salt;L-5- Methyl leucovorin;Calcium (S)-2-(4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino;CALCIUML-5-METHYLTETRAHYDROFOLATE;(6S)-N-[4-(2-Amino-1,4,5,6,7,8,-hexahydro-5-methyl-4-oxo-6-pteridinylmethylamino)benzoyl]-L-glutaminsure, Calciumsalz (1:1);Calcium levomefolate;L-5-Methyltetrahydrofolate calcium;METHYL FOLATE CALCIUM SALT(METAFOLIN)(P)CAS:151533-22-1MF:C20H27CaN7O6MW:501.56EINECS:691-636-3Levomefolate calcium is an organic calcium salt of (6S)-5-methyltetrahydrofolic acid. It has a role as an antidepressant. Itcontains a (6S)-5-methyltetrahydrofolate(2-).ITEMSPECIFICATIONRESULTTest methodAppearanceWhite to light yellow crystalline powderCompliesVisualIdentificationIRIR should be identical with that of referenceCompliesUSP43 CalciumA 5-mg/mL solution meets the requirements HPLCThe retention time of the major peak in the chromatograme of Assay preparation corresponds tothat in the chromatograme of the standard preparation, as obtained in the Assay Elemental impuritiysBoron≤50PPMCompliesUSP43 Platinum≤10PPMComplies Arsenic≤1.5PPMComplies Cadmium≤0.5PPMComplies Lead≤1.0PPMComplies Hg≤1.5PPMComplies Residual solventEthanol≤0.5% 2-Propanol≤0.5%CompliesUSP43Related compounds4-Aminobenzoylgluta mic acid≤0.5%NDUSP43 4a-Hydroxy-5-methyl-tetrahydrofolic acid≤1.0%ND (6R)-Mefox/ND (6s)-Mefox≤1.0%(sum of 6R and 6S)0.31% Tetrahydrofolic acid≤0.5%ND 7,8-Dihydrofolic acid≤0.5%ND Folic acid≤0.5%ND 5,10-Methylenetetrah-yd rofolic acid≤0.5%ND 5-Methyltetrahydrop-teroic acid≤0.5%ND Dimethyltetrahydrofolic acid≤0.15%ND Total Impurites≤2.5%1.21% D-5-Methylfolate≤1.0%0.24%USP43Calcium (on the anhydrous and solvent-free basis)7.0%-8.5%7.8%USP43Water determination6%-17.0%16.3%Karl FischerParticle size90% pass 80 meshCompliesSieveChloride≤0.5%CompliesUSP43Heavy metals≤10ppmCompliesUSP43Total microbacterial count≤100CFU/gCompliesCP2015Yeast &Mould≤10CFU/gCompliesCP2015Escherichia Coli presenceNegativeNegativeCP2015SalmonellaNegativeNegativeCP2015Staphylococcus aureusNegativeNegativeCP2015P. aeruginosaNegativeNegativeCP2015Candida albicansNegativeNegativeCP2015ClostridiaNegativeNegativeCP2015Calcium L-5-methyltetrahydrofolate95.0%-102.0%98.9%USP43L-5-methyltetrahydrofolate≥85.0%90.1%USP43ConclusionThe results conforms with the USP43 standard. Uses:Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.As adjuvant therapy for colon cancer, rectal cancer.Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued. Quality Control: We have advanced precision instruments and equipment ,so we can independently control product content, pesticide residue, physical and chemical properties, microorganisms, heavy metals and other quality indicators. Our goal is zero complaints.We have our own plant base. Weeding by hand, no pesticides or herbicides used. Control quality from the source.Packaging:The product is packed in 25kg or 10kg fiber drum.It should be stored in its original packing or in a suitable sealed container and kept in a clean and dry place. Storage conditions should preferably be a sheltered environment with limited temperature variations and low humidity levels. Direct contact with water or any other liquid will result in product caking. Under normal circumstances, the use of this product will not cause any undue health hazards. Precautions must be taken to prevent solid or liquid product to contact with skin or eyes.Customization ServiceR&D and Production: We specializes in the development of functional materials and has provided a number of development and improvement solutions.Granular Production: Our granulation and superfine pulverization can improve bulk density to filling capsules and tablets. and increase water solubility.Blending and Mixing
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