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IPDB › China Industry › Chemicals › Pharmaceutical Intermediate

China, Chinese Chemical Research Larazotide Acetate Peptide Larazotide¹ Industrial Products Supplier Manufacturer Details, price list catalog:

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Pharmaceutical Intermediate Larazotide Larazotide Acetate

Xi'an Qiushi Co., Ltd.

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Product Description Chemical Research Larazotide Acetate Peptide LarazotideProduct DetailsProduct NameLarazotideAppearanceWhite PowderAssay99%MW725.83MFC32H55N9O10Larazotide (CAS number 258818-34-7) is a peptide that is an orally active zonulin antagonist.Larazotide has antiviral activity against varicella zoster virus (VZV), with EC50 values of 44.14 and 59.06 μ M for OKA and 07-1 strains, respectively. Larazotide can be used for research on celiac disease and infections. Larazotide (1-100 μ M; 5d) affects the growth of Vero cells. Larazotide (1-100 μ M; 3d) exhibits antiviral activity against varicella zoster virus (VZV), with EC50 values of 44.14 and 59.06 μ M for OKA and 07-1 strains, respectively. Larazotide (100 μ M; 3h) inhibits the translocation of alcohol soluble proteins across Caco-2 monolayers. Larazotide (12.5 mM; 1h) inhibits ZO-1 redistribution and actin cytoskeleton rearrangement induced by PTG in IEC6 cells.Application&FunctionPharmacological effects of LirizoleLarezole can promote the normalization and tight junctions of intestinal cells in patients with celiac disease in vivo, preventing the breakdown products of gluten, such as gliadin, from entering the systemic circulation and causing inflammatory reactions. This mechanism of action makes it a potential option for the treatment of celiac disease.In addition, Lirizole has antiviral activity against varicella zoster virus (VZV), with EC50 values of 44.14 and 59.06 μ M for OKA and 07-1 strains, respectively. This suggests that it may play a role in the study of viral infections.Specification

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