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China, Chinese Zoledronic Acid CAS No. 118072-93-8 Orazol1 Industrial Products Supplier Manufacturer Details, price list catalog:
China Industrial Products Supplier Manufacturer List Catalog
Specialized Preparation2- (imidazole-1-yl) -1-Acetic Acid HClCgp-42446; Zoledronic Acid API
Ningbo Samreal Chemical Co., Ltd.
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Product Description Zoledronic acid monohydrate is a white powder, odorless, easily soluble in sodium hydroxide solution, slightly soluble in water, insoluble in methanol, ethanol, and dichloromethane. Melting point: 237°C-240°C. Zoledronic acid has an alkaloid structure and can form an orange-yellow precipitate with potassium bismuth iodide. Take 20 mg of this product and add it to 20 mL of water, pH should be between 2.0-3.5.Pharmacological effectsZoledronic acid is a third-generation bisphosphonate compound and an effective inhibitor of bone resorption. This drug can inhibit osteoclast activity, induce osteoclast apoptosis, and prevent the reabsorption of mineralized bone and cartilage by binding to bones. It can also inhibit the increased osteoclast activity and bone calcium release caused by various stimulating factors released by tumor cells, effectively controlling hypercalcemia.Chemical properties: White crystalline powder. Uses: Antitumor drug.The side effects of zoledronic acid include fatigue, anemia, muscle pain, fever, and swelling in the hands and feet. The first time using zoledronic acid often presents symptoms similar to a cold. Subsequent uses of the drug do not usually cause these symptoms, which is believed to be due to the potential activation of human γ, δ T cells by the drug. Zoledronic acid is quickly processed by the kidneys. Therefore, patients with deteriorated kidney function or kidney disease are not suitable for using this medication. There have also been cases of rare osteonecrosis of the jaw as a side effect in multiple myeloma patients using this drug, especially those who have had teeth extracted.
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