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China, Chinese Marya China Automatic Vacuum Freeze Drying Machine with CE Approval1 Industrial Products Supplier Manufacturer Details, price list catalog:
China Industrial Products Supplier Manufacturer List Catalog
Chemical Drying EquipmentFreeze Drying MachineAutomatic Freeze Drying Machine
Shanghai Marya Pharmaceutical Engineering & Project Co., Ltd.
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Product Description Marya China Automatic Vacuum Freeze Drying Machine with CE ApprovalShanghai Marya is a premier provider of comprehensive pharmaceutical turnkey projects, encompassing pharmaceutical factory design, R&D, machinery manufacturing, shipment, installation, commissioning, and a robust suite of after-sales services.Main ApplicationsThe working principle of the vacuum freeze dryer is to utilize sublimation under vacuum conditions. Water in the pre-frozen medicine sublimates directly from ice to vapor without passing through the liquid phase, achieving the freeze-drying goal. This sophisticated machine integrates a refrigeration system, vacuum system, heat conduction oil heating system, and dehumidification system. Featuring an innovative box structure, it is available in various models including laboratory, raw material, pilot production, and industrial freeze-drying machines. The freeze-dried products are spongy, dry-shrinking, possess excellent rehydration, minimal moisture content, and can be stored and transported at room temperature for an extended period. This technology is widely applied in drying raw materials, Chinese medicine pieces, biological products, vaccines, blood products, active substances, antibiotics, food, fruit, chemical, pharmaceutical intermediates, and other materials. Phase 1: Freezing Phase Graph depicting the operational mechanics of a freeze dryer, illustrating the ideal freeze drying pressure and temperature.This phase is paramount. Freeze dryers employ various techniques to freeze products.The freeze dryer cools materials below their triple point to ensure sublimation occurs instead of melting, thus preserving the material's physical form.Freeze dryers can most effectively process large ice crystals, created through slow freezing or annealing. However, in biological materials, overly large crystals can rupture cell walls, leading to suboptimal results. Rapid freezing is employed to avert this.For materials prone to precipitation, annealing may be used. This involves rapid freezing followed by a temperature increase to promote crystal growth. Phase 2: Primary Drying (Sublimation) During the primary drying (sublimation) phase, pressure is reduced and heat is applied to the material, enabling water to sublimate.The vacuum accelerates sublimation, while the cold condenser provides a surface for water vapor to solidify and also safeguards the vacuum pump from water vapor damage.Approximately 95% of the water in the material is removed during this phase.Primary drying can be a prolonged process, as excessive heat can alter the material's structure. Phase 3: Secondary Drying (Adsorption) The final phase is secondary drying (adsorption), where ionically-bound water molecules are removed.By elevating the temperature higher than in the primary drying phase, the bonds between the material and water molecules are broken.Freeze-dried materials retain a porous structure.Post-process, the vacuum can be broken with an inert gas before the material is sealed.Most materials can be dried to a residual moisture content of 1-5%. Notice:Key terms related to freeze dryers include:Eutectic Point or Eutectic TemperatureThe point at which the product exists solely in the solid phase, indicating the minimum melting temperature. Not all products have a eutectic point, and some may have multiple eutectic points.Critical Temperature: During the sophisticated process of freeze drying, the maximum permissible temperature of the product before its quality begins to degrade through melt-back or collapse.Crystalline : The material crystallizes upon freezing and possesses a eutectic point or multiple eutectic points. Rapid freezing generates small, hard-to-dry crystals; annealing can facilitate the formation of larger, more manageable crystals.Amorphous : These are multi-component mixtures that do not crystallize and lack a eutectic point, turning instead into a 'glass.' Freeze drying must occur below the glass transition temperature to ensure product integrity.Collapse : The critical point at which the product softens to the extent that it can no longer maintain its structural integrity, leading to several potential issues:1. Loss of physical structure2. Incomplete drying3. Decreased solubility4. Significant material ablation (splat)Parameters Shelf temp (oC)-50 to 70Final condenser temp (oC)-80Vacuum Degree (Pa)<10Condenser capacity (Kg/24h)15Qty of shelf4+1Distance between shelves(mm)90Liquid material loading capacity (L)20Cooling modeAir coolingCap seal methodHydraulic pressure ISO Certificate of Marya ProductsAbout Us WHY CHOOSE US?We offer comprehensive DQ, IQ, PQ, and OQ documentation services tailored to ensure your equipment meets all necessary qualifications.Our team specializes in overseas machine installation and commissioning, providing seamless integration and setup for your operations.Benefit from our complimentary training services designed to empower your employees with the skills and knowledge they need.Enjoy peace of mind with our one-year guarantee, ensuring your investment is protected.Our dedicated technical support team is available 24/7 via email to assist you with any issues or questions.Our expert installation team is ready to travel to your country to handle the entire installation process professionally.Take advantage of our user-friendly English software, comprehensive user manual, and detailed instructional videos.We eagerly anticipate a successful collaboration with you.
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